Biogen Announces EMBRACE, a New Phase 2 Clinical Trial

Biogen, in partnership with Isis Pharmaceuticals, has announced a new Phase 2 clinical trial, called EMBRACE.

EMBRACE is a multi-center, Phase 2 clinical study evaluating the safety and exploratory efficacy of the investigational drug, ISIS-SMNRx, (ISIS 396443) in patients with infantile or childhood-onset Spinal Muscular Atrophy (SMA). The study is a double-blind, randomized, sham-procedure controlled study, designed to examine the safety & exploratory efficacy of ISIS-SMNRx in approximately 20 patients with SMA over a 14 month period.

Please see the EMBRACE Q&A for details on enrollment criteria, or contact one of the participating trial centers for more information.

Ongoing Clinical Trials

EMBRACE is the fourth ongoing trial testing ISIS-SMNRx. The others are:

  • ENDEAR, a Phase 3 clinical trial testing infants with SMA type I
  • CHERISH, a Phase 3 clinical trial testing children age 2-12, with onset of symptoms at age six months or later
  • NURTURE, a Phase 2 clinical trial testing very young infants who are genetically predisposed to SMA but not yet showing symptoms

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